Connecting Enzymes

Let us show you that it is not only better to use enzymes,
but also how to use enzymes better.

The future for the industrial application of enzymes is bright. New enzymes are becoming available, the efficacy of enzymes is increasing and the manufacturing costs are going down. This opens new applications and new markets. New applications in pharma, in food, in lipids and in specialty chemicals. New markets such as second generation bio-ethanol.

We as CLEA Technologies are closely involved in these developments on several levels: in application development, in implementation and of course as supplier of (immobilized) enzymes. Innovations like our ferromagnetic cross-linked enzymes, that can easily be removed even when other solids are present, are a good example of our dedication.

Our partners and projects are diverse: custom immobilizations for enzyme manufacturers and/or users; optimization and implementation of enzymatic processes in pharma or oleochemicals; cost reduction by enzyme recycling in food and beverages. Our scientists are trained in organic chemistry, chemical process technology, biocatalysis and pharmaceutical chemistry. Read more about us and let us know what we can do for you.

Markets

Pharma and fine chemicals

Markets

First and second generation biofuels:
bioethanol, biodiesel, biorefineries

Markets

Food and beverages

Markets

Oleochemicals

Markets

Pharma and fine chemicals

Markets

First and second generation biofuels:
bioethanol, biodiesel, biorefineries

Markets

Food and beverages

Markets

Oleochemicals

We strongly believe that the future for industrial application of enzymes is bright.

The world market for enzymes is around 6 billion euros and growing above average. In some applications, like in laundry detergent, as medication or as food or feed additive, enzyme immobilization will be unlikely. In other applications though, whether this is in pharmaceutical manufacturing, in diagnostics, in food production or in biofuels, enzyme immobilization may open the door to significant cost reduction. Where the future for  industrial use of enzymes may be bright, the future for immobilized enzymes will be shining.

With more than a decade of experience in biocatalysis, we help our clients with services and products. With process development and with enzyme immobilization. We serve a very diverse customer base; from start-ups to Fortune 500 companies; from big pharma names to second generation bio-fuel engineering companies; from food production to diagnostics. With all our customers, we share the passion for chemistry. As no other, we understand that a green process is only acceptable if the cost is right. In this respect, all markets are the same. Read more about our markets.

Technology

Let us show you that
it is not only better to use enzymes,
but also how to use enzymes better.

Technology

Let us show you that
it is not only better to use enzymes,
but also how to use enzymes better.

Technology

Let us show you that
it is not only better to use enzymes,
but also how to use enzymes better.

Technology

Let us show you that
it is not only better to use enzymes,
but also how to use enzymes better.

Making green chemistry affordable

The use of biocatalysts can have major advantages: in increased product quality, reduced downstream processing and a much smaller environmental footprint. This is not enough. Biocatalysis must also be cost competitive. Our focus on process optimization and on enzyme recycling makes CLEA Technologies the right partner to also achieve the cost reduction you are looking for. We have proven this with expensive enzymes like ketoreductases in pharma, with more common enzymes like CalB in pharma and oleochemicals and even with low cost enzymes used in first and second generation biofuels.

We have proven this with our proprietary cross-linked enzyme aggregates and with carrier based enzymes. Our novel ferromagnetic CLEAs (mCLEAs) are not only a cost effective means of enzyme immobilization but are also easily and effectively separated, even at very high flow rates, even in the presence of other solids.

Our drive for perfection and innovation will help you make your enzymatic processes work better and more cost effective. Read more about our technology.

Products

Cross-Linked Enzyme Aggregates

Products

Ferromagnetic
Cross-Linked Enzyme Aggregates

Products

Carrier based immobilized enzymes

Products

Soluble enzymes

Products

 Discovery platforms

Products

Cross-Linked Enzyme Aggregates

Products

Carrier based immobilized enzymes

Products

Ferromagnetic CLEAs

Products

Discovery platforms

CLEA Technologies as (immobilized) enzyme supplier

We are not an enzyme manufacturer. For all our products we either use your enzyme or commercially available enzymes. The vast majority of the products we deliver are in the first category: immobilized versions of customer specific enzymes. For example ketoreductases in pharma, amylases and cellulases for bio-ethanol or saccharide isomerases for food. Very diverse enzymes for very diverse applications.

We supply enzymes on gram scale, on kilo scale and on full industrial scale. Usually, these products are customer specific and not on our public portfolio. Some broadly applicable enzymes like CalB and Alcalase (TM), we supply off the shelf as (m)CLEA or on beads.
Next to that, both for research labs and universities, we have developed screening kits of the most popular enzyme families: lipases, proteases and nitrile hydratases. Recently, we added a special CaLB kit to our portfolio with different forms of immobilization. Read more about our products.

Services

Route development

Services

Enzyme screening

Services

Enzyme immobilizations

Services

Independant supplier of
soluble and immobilized enzymes

Services

Route development

Services

Enzyme screening

Services

Enzyme immobilizations

Services

Independant supplier of
soluble and immobilized enzymes

Our expertise: biocatalysis and enzyme immobilization

With more than a decade of experience, our knowledge of green chemistry has helped many of our customers with the implementation of biocatalytic processes, with optimization of existing processes or with severe cost reduction by recycling immobilized enzymes instead of using soluble enzymes. We have done so for a vast number of companies in pharma, fine chemicals, oleochemicals, food and biofuels.

Whether your request is to optimize enzyme immobilization, to screen enzymes or to fully develop an alternative economically viable and environmentally sound process, CLEA Technologies will be your partner.

We can supply you with immobilized or soluble enzymes: as individual products or as a dedicated discovery platform at attractive costs. Read more about our services.

Partnerships

In biofuels

Partnerships

In pharmaceuticals

Partnerships

In EU-sponsered projects

Partnerships

With enzyme manufacturers

Partnerships

In cosmetics

Partnerships

In biofuels

Partnerships

In pharmaceuticals

Partnerships

In EU-sponsered projects

Partnerships

With enzyme manufacturers

Partnerships

In cosmetics

Curiosity brings us together, results bring us further.

At CLEA Technologies, we subscribe to the vision that research and development is the best way to achieve progress. Since our beginning in 2002, research and development is the core of our company.

Most of our time we spend on R&D: with our partners, with our customers or on our own account. We work within EU frameworks like FP7, Horizon2020 or the Biobased Industry Consortium (BIC). We work on route development, on process and manufacturing optimization, on enzyme immobilization, on enzyme recycling. Our partners in these projects can be found in all markets we are active: in pharmaceuticals, in flavours and fragrances, in oleochemicals, in all kinds of biofuels and in CO2 capture. Projects that are beneficial to the environment, beneficial to the economy.

Constantly, new alliances are formed: in cooperation with large enterprises, with other SME’s, with research institutes or with universities. We work on new products and new applications to conquer a market.

Partners can be enzyme manufacturers to supply to/from or to license our technology, technology providers to implement our immobilized enzymes or end-users such as manufacturers of API’s, cosmetic esters, biofuels or foodstuff.

In our business model, we are very flexible. Sometimes we are a CRO, we license our technology, we custom manufacture or put a jointly developed product on the market.

Whenever you have an interest in biocatalysis or immobilized enzymes, we can be your partner. Read more about our partnerships.